abstract：:Nebivolol is a new selective beta 1-adrenergic blocking agent, that possesses a peculiar pharmacodynamic profile and an original chemical structure, by which it differs from traditional beta 1-blockers. Nebivolol is a racemic mixture of two enantiomers in equal ratios. It is endowed with a highly selective beta 1-bloc...

journal_title：Pharmacological research

authors： Mangrella M,Rossi F,Fici F,Rossi F

更新日期：1998-12-01 00:00:00

abstract：:The effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (LPO) and on the activities of superoxide dismutase (SOD) and catalase (CAT) were investigated in male Swiss mice. Administration of betel leaf extract exhibite...

journal_title：Pharmacological research

authors： Panda S,Kar A

更新日期：1998-12-01 00:00:00

abstract：:The possible involvement of adenosine 5'-triphosphate (ATP) receptors in the function of the hippocampus is reviewed. The involvement of these receptors in the hippocampus is suggested by data that ATP is released from hippocampal slices [1] and that it also induces fast synaptic currents in cultured hippocampal neuro...

journal_title：Pharmacological research

authors： Inoue K

更新日期：1998-11-01 00:00:00

abstract：:A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and...

journal_title：Pharmacological research

authors： Nishida K,Ohta Y,Ishiguro I

更新日期：1998-11-01 00:00:00

abstract：:The objective of the study was to investigate possible changes in vancomycin serum levels induced by cardio-pulmonary bypass (CPB). Ten cardiac patients (seven males, three females, aged between 56 and 81), who underwent cardiac surgery requiring CPB, took part in the study. Vancomycin (15 mg kg-1) was intravenously i...

journal_title：Pharmacological research

authors： Miglioli PA,Merlo F,Grabocka E,Padrini R

更新日期：1998-10-01 00:00:00

abstract：:There is evidence that hydrazine, a metabolite of isoniazid, plays an important role in the mechanism of isoniazid-induced hepatotoxicity. Hydrazine has been reported to be metabolised by NADPH cytochrome P-450 reductase (reductase) to reactive and potentially toxic intermediates. The present study was designed, using...

journal_title：Pharmacological research

authors： Sarich TC,Adams SP,Wright JM

更新日期：1998-09-01 00:00:00

abstract：:The present investigation was undertaken to suggest the involvement of free radicals in the pathogenesis of pyloric ligation induced ulcers in rats. Lipid peroxidation product (MDA), antioxidant contents and secretory activity have been studied in the rat stomach at different time intervals after pylorus ligation indu...

journal_title：Pharmacological research

authors： Rastogi L,Patnaik GK,Dikshit M

更新日期：1998-08-01 00:00:00

abstract：:The growing size of trials on primary and secondary prevention of acute coronary syndromes characterised by very broad inclusion criteria may seem logical to 'trialists', who reason that the the broader the inclusion criteria, the easier it is to recruit large numbers of patients in a short period of time and the more...

journal_title：Pharmacological research

authors： Monaco C,Cianflone D,Summaria F,Maseri A,Crea F

更新日期：1998-06-01 00:00:00

abstract：:In spite of continuous research in the field of bronchial asthma, still no satisfactory drug is available. Recently a new class of oligopeptide exhibited antiallergic activity by inhibiting the synthesis of IgE antibody. The analogue of ADSDGK (94-335) has shown antiallergic activity in experimental models. The 94-335...

journal_title：Pharmacological research

authors： Singh R,Nath A,Gupta PP,Shulka M,Khare SK,Kundu B

更新日期：1998-05-01 00:00:00

abstract：:A study was carried out relating to the anticholinergic action of clonidine on the cardiovascular responses to i.c.v. injection of neostigmine, a quaternary anticholinesterase, in conscious sham-operated animals and rats with sinoaortic denervation, 7 days after the corresponding operation. Neostigmine (0.1-1 microgra...

journal_title：Pharmacological research

authors： Taira CA

更新日期：1998-04-01 00:00:00

abstract：:Several studies on disease and treatment effects on neurohormones have been conducted with small numbers of patients, using one blood sample as representative of their states. The aim of this study was to assess the within-patient variability of plasma concentrations of several hormones and cytokines of recent interes...

journal_title：Pharmacological research

authors： Masson S,Latini R,Bevilacqua M,Vago T,Sessa F,Torri M,Anesini A,Salio M,Pasotti E,Agnello D,Santoro L,Catania A,Ghezzi P,Moccetti T,Maggioni AP

更新日期：1998-03-01 00:00:00

abstract：:The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and ac...

journal_title：Pharmacological research

authors： Cinelli M,Magnelli L,Chiarugi V

更新日期：1998-02-01 00:00:00

abstract：:The investigation was aimed at investigating whether the dopaminergic projection arriving at the nucleus septi lateralis (NSL) is involved in the facilitatory effect of vasopressin (AVP) on memory retrieval. The bilateral 6-OHDA lesions to the NSL were made in 20 male Wistar rats before testing the intracerebroventric...

journal_title：Pharmacological research

authors： Winnicka MM,Wiśniewski K

更新日期：1998-02-01 00:00:00

abstract：:The effect of the inhalation of vaporized ethanol on injected [1-14C]pyruvate kinetics was studied in mice. The [1-14C]pyruvate kinetics were modelled by means of a four-compartment closed model, i.e. injected site, blood, periphery and expired 14CO2. The results show that the inhalation of vaporized ethanol can stimu...

journal_title：Pharmacological research

authors： Wu G

更新日期：1998-01-01 00:00:00

abstract：:Pharmacokinetics is a relatively young branch of the life sciences, which has developed rapidly in the last 15-20 years, thanks to a series of analytical achievements that have allowed drug concentrations to be measured in biological matrices with highly selective and sensitive methods. Most old drugs and all new drug...

journal_title：Pharmacological research

authors： Marzo A

更新日期：1997-12-01 00:00:00

abstract：:We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons to the central amygdala is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory motivated affectively and also on recognition me...

journal_title：Pharmacological research

authors： Winnicka MM,Braszko JJ,Wiśniewski K

更新日期：1997-11-01 00:00:00

abstract：:N-acetyl penicillamine (NAP), a derivative of penicillamine and copper chelator has been employed as a potential protector of host stress organ injury during Plasmodium berghei infection in mice. Intramuscular injection of NAP (60 mg kg-1 body wt for 10 days) to P. berghei mice was able to restrict the hepato- and spl...

journal_title：Pharmacological research

authors： Srivastava P,Arif AJ,Singh C,Pandey VC

更新日期：1997-10-01 00:00:00

abstract：:The potential for modulating gene expression by the use of antisense oligonucleotides has become increasingly interesting in recent years. Antisense oligonucleotides are complementary nucleic acid fragments that hybridize to target sequences within RNA to form a DNA-RNA duplex, resulting in the block of translation of...

journal_title：Pharmacological research

authors： Alama A,Barbieri F,Cagnoli M,Schettini G

更新日期：1997-09-01 00:00:00

abstract：:Lipid peroxidation increased both in the liver homogenates and in the hepatic mitochondrial fraction of bile duct ligated (BDL)-rats. Although mitochondrial superoxide dismutase (SOD) activity did not change in the liver, glutathione (GSH) levels and glutathione peroxidase (GSH-Px) activity decreased in hepatic mitoch...

journal_title：Pharmacological research

authors： Alptekin N,Mehmetçik G,Uysal M,Aykaç-toker G

更新日期：1997-09-01 00:00:00

abstract：:Local microcirculatory dysfunction within the pancreatic gland might be an important factor in the conversion of oedematous to necrotizing pancreatitis. Therapeutic agents, improving the pancreatic blood flow, might be valuable in acute pancreatitis treatment. An influence of nitric oxide, heparin and procaine treatme...

journal_title：Pharmacological research

authors： Dobosz M,Hac S,Mionskowska L,Dobrowolski S,Wajda Z

更新日期：1997-08-01 00:00:00

abstract：UNLABELLED:The purpose of this study was an attempt to extrapolate favorable observations on the effects of magnesium on platelets and haemostasis from animal models to humans. Intravenous magnesium in the treatment of acute myocardial infarction has been tested in several large clinical trials and remains controversia...

journal_title：Pharmacological research

authors： Serebruany VL,Herzog WR,Schlossberg ML,Gurbel PA

更新日期：1997-07-01 00:00:00

abstract：:The antinociceptive and motor effects of the hydrophilic alpha 2-adrenoceptor agonist ST-91 were studied after intrathecal administration to male Wistar rats in different heat-pain tests and different test settings. Intrathecal administration of ST-91 caused a dose-dependent increase in hind paw licking latency in the...

journal_title：Pharmacological research

authors： Horváth G,Dobos I,Liszli P,Klimscha W,Szikszay M,Benedek G

更新日期：1997-06-01 00:00:00

abstract：:A bovine dopamine transporter (bDAT) cDNA was transfected into CV-1 cells, a cell line that lacks vesicular storage and release mechanisms. Using this cell line, the effects of neuroleptic drugs on DAT-mediated uptake and release of dopamine (DA) were examined. All of the neuroleptic drugs tested, inhibited DA uptakes...

journal_title：Pharmacological research

authors： Lee Sh,Oh Dy,Jung Sc,Kim Ym,Cho Hk,Koh Jk,Lee Ys

更新日期：1997-05-01 00:00:00

abstract：:PI3K was originally discovered as a lipid kinase involved in the phosphorylation of the inositol ring in position -3, leading to the synthesis of phosphatidyl-inositol-3-4 bisphosphate. The enzyme purified from rat liver is an heterodimer of two subunits of 85 and 110 KD respectively: it phosphorylates the D3 hydroxyl...

journal_title：Pharmacological research

authors： Chiarugi V

更新日期：1997-04-01 00:00:00

abstract：:This paper describes a new sensitive gas chromatographic method with electron capture detector to assay estazolam in human plasma, which has been developed and validated for pharmacokinetic purposes. The drug and the internal standard (triazolam) were extracted from plasma buffered at pH 9.0 into toluene and analysed ...

journal_title：Pharmacological research

authors： Dal Bo L,Verga F,Marzo A,La Commare P,De Vito ML

更新日期：1997-04-01 00:00:00

abstract：:The effect of different L-histidine concentrations on human mammary tumour cell (CG5) proliferation was studied to test the hypothesis of a role of histidine in modulating sex steroid-regulated cell proliferation. Cell growth was only possible in the 10(-5) M and 10(-2) M range, while its inhibition by medroxyprogeste...

journal_title：Pharmacological research

authors： Ghezzo F,Racca S,Conti G,Berta GN,D'Avolio A,Abbadessa G,Gambino G,Di Carlo F

更新日期：1997-02-01 00:00:00

abstract：:The study was undertaken using selected pharmacodynamic parameters to describe the effects of porcine galanin(1-29)-NH2; porcine galanin fragments; galantide; porcine galanin(1-14)-[alpha-aminobutyric acid8]scyliorhinin-I and the analogues of the latter peptides on rat isolated gastric fundus muscle. All tested peptid...

journal_title：Pharmacological research

authors： Korolkiewicz R,Sliwiński W,Rekowski P,Halama-Borowiec A,Mucha P,Szczurowicz A,Korolkiewicz KZ

更新日期：1997-01-01 00:00:00

abstract：:The effect of chloroquine and other antimalarial drugs on glutamate dehydrogenase activity was studied in liver and renal mitochondria as well as in kidney-cortex tubules of rabbit. In permeabilized mitochondria, with free access of substrates and drugs to glutamate dehydrogenase, 100 microns chloroquine decreased bot...

journal_title：Pharmacological research

authors： Jarzyna R,Lenarcik E,Bryła J

更新日期：1997-01-01 00:00:00

abstract：:The role of the angiotensin AT1 receptors in certain behavioural effects of angiotensin II (Ang II), using their selective antagonist losartan (DuP 753), was assessed. Ang II, given intracerebroventricularly (ICV) at the dose of 1 nmole, significantly improved object recognition, learning of conditioned avoidance resp...

journal_title：Pharmacological research

authors： Kułakowska A,Karwowska W,Wiśniewski K,Braszko JJ

更新日期：1996-09-01 00:00:00

abstract：:The renal and metabolic effects of chronic carnitine administration were evaluated in the early stages of experimentally-induced renal failure. Laevo-carnitine (n = 5), Propionyl-carnitine (n = 5) both at 200 mg kg-1 of body weight, or vehicle (physiological saline solution, 0.4 ml kg-1 body weight, n = 5) were admini...

journal_title：Pharmacological research

authors： Palomba D,Pes GM,Demontis MP,Varoni MV,Deiana L,Anania V

更新日期：1996-09-01 00:00:00

abstract：:In the present study, hyperglycaemia was induced by intraperitoneal injection of streptozotocin (65 mg/kg). Treatment with glibenclamide (GB) in a dose of 0.45 or 0.9 mg/kg significantly decreased plasma glucose level in a dose-related manner. Administration of nadolol (ND) in a dose of 5 or 10 mg/kg did not affect pl...

journal_title：Pharmacological research

authors： Abdel Aziz AH,Moustafa AM,Abd Ellah MF,el-Mazar MA

更新日期：1996-07-01 00:00:00

abstract：:Cardamom seeds are widely used for flavouring purposes in food and as carminative. Little information has been reported on their pharmacological and toxicological properties or, for their volatile oil which constitutes about 5% of the seed's total weight. A comparative study of the anti-inflammatory activity of the oi...

journal_title：Pharmacological research

authors： al-Zuhair H,el-Sayeh B,Ameen HA,al-Shoora H

更新日期：1996-07-01 00:00:00

abstract：:Oxaceprol, an established therapeutic agent for osteoarthritis, had no effect on macrophage prostaglandin E2 release in vitro and inhibited carrageenan paw oedema at high doses (18-150 mg/kg p.o.). In the same dose range, oxaceprol was comparable to indomethacin (3 mg/kg p.o.) as an inhibitor of yeast hyperalgaesia an...

journal_title：Pharmacological research

authors： Ionac M,Parnham MJ,Plauchithiu M,Brune K

更新日期：1996-06-01 00:00:00

abstract：:The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7 mM D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl, monoethyl, monobutyl, dibutyl, dipropyl and diallyl esters of succini...

journal_title：Pharmacological research

authors： Björkling F,Malaisse-Lagae F,Malaisse WJ

更新日期：1996-04-01 00:00:00

abstract：:The insulinotropic action of the meglitinide analogues KAD-1229, A-4166 and repaglinide was examined in rat pancreatic islets deprived of exogenous nutrient or incubated in the presence of nutrient secretagogues such as D-glucose and the methyl esters of pyruvic acid, succinic acid and glutamic acid. The meglitinide a...

journal_title：Pharmacological research

authors： Bakkali Nadi A,Zhang TM,Malaisse WJ

更新日期：1996-03-01 00:00:00

abstract：:Possible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated. R-PIA (0.05 mg kg-1), an adenosine analogue, and caffeine (20 mg kg-1), an adenosine receptor antagonist, significantly decreased and increased locomotor activity, respectively. Ca2+ channel blocker nifed...

journal_title：Pharmacological research

authors： Eroglu L,Tuna R,Caglayan B

更新日期：1996-02-01 00:00:00

abstract：:Because many Ca2+ channel blocking agents are known to cause adverse systemic effects, in this study we tested the haemodynamic side effects of nimodipine with and without a mild hypoxic-ischaemic (HI) insult in a newborn piglet model. Fifteen min after completing a brief period of asphyxia we gave i.v. nimodipine as ...

journal_title：Pharmacological research

authors： Raju TN,John E,Shankararao R,Fornell L,Vasa R,Abu-Harb M

更新日期：1996-01-01 00:00:00

abstract：:The mechanism for the pathological increase in cell death in various disease states e.g. HIV immunodefficiency or even ageing or Alzheimer's disease, occurs by complex and as yet undefined mechanism(s) related to immunological, virological or biochemical disturbances (i.e. energy depletion, oxidative stress, increased...

journal_title：Pharmacological research

authors： Virmani MA,Biselli R,Spadoni A,Rossi S,Corsico N,Calvani M,Fattorossi A,De Simone C,Arrigoni-Martelli E

更新日期：1995-12-01 00:00:00

abstract：:The effect of flumazenil (FLU) on plasma protein binding of diazepam (DZ), nordiazepam (ND) and oxazepam (OX) was determined in plasma from drug-naive dogs to which graded concentrations of tested drugs alone and in combination were added. The results revealed that as the concentration of FLU added to plasma alone was...

journal_title：Pharmacological research

authors： Wala EP,Sloan JW

更新日期：1995-11-01 00:00:00

abstract：:Bioequivalence studies are mainly required to demonstrate the interchangeability of multisource pharmaceutical products, usually called generics. A pivotal investigation projected and conducted in compliance with specific guidelines allows a replicative company to register a generic drug via an ANDA (abbreviated new d...

journal_title：Pharmacological research

authors： Marzo A

更新日期：1995-10-01 00:00:00